TOKYO (Reuters) - Takeda Pharmaceutical Co Ltd said on Wednesday it had posted a full-year operating profit, surprising analysts who had expected it to make a loss on the hefty costs that came with last year's $59 billion takeover of Shire Plc. Operating profit for Japan's largest drugmaker in the year that ended in March came in at 100 billion yen ($933.62 million). That compares with its own earlier estimate of a 10 billion yen profit and a consensus estimate of a 12.7 billion yen loss..