(Reuters) - A Missouri trial court judge has affirmed the massive $4.69 billion (3.63 billion pounds) verdict against Johnson & Johnson in a case involving 22 women and their families who alleged the company's talc-based products, including its baby powder, contain asbestos and caused them to develop ovarian cancer.J&J in a statement on Wednesday said it would continue to pursue all available appellate remedies. The company, which denies the allegations and says its talc is safe, previously..